反应详情

温度

45 °C

To a solution of 1-(2-methoxy-vinyl)-4-trifluoromethylbenzene (10.5 g, 0.052 mol, from step (i) above) in 158 ml acetone was added 107.3 ml 3 M HCl and stirred at 45° C. for 4 h. Acetone was evaporated under reduced pressure and the residue was partitioned between water and ether. Organic layer was washed with NaHCO3, brine and dried over sodium sulfate. Solvent evaporation under reduced pressure afforded the sub-title compound (9.4 g ) as pale yellow liquid. This was directly taken for next step without further purification.

1. customAcetone was evaporated under reduced pressure
2. customthe residue was partitioned between water and ether
3. washOrganic layer was washed with NaHCO3, brine
4. dry with materialdried over sodium sulfate
5. customSolvent evaporation under reduced pressure