Chloride → 1-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

HRID 199245Notes

Reaction equation

HRID 199245 reaction equation
[Al+3:14].[C:1]([CH3:2])(=[O:3])[N:4]1[CH2:5][CH2:6][CH:7]([C:8](=[O:9])[Cl:10])[CH2:11][CH2:12]1.[Cl-:13].[Cl-:15].[Cl-:16].[F:17][c:18]1[cH:19][cH:20][cH:21][c:22]([F:23])[cH:24]1>>[C:1]([CH3:2])(=[O:3])[N:4]1[CH2:5][CH2:6][CH:7]([C:8](=[O:9])[c:19]2[c:18]([F:17])[cH:24][c:22]([F:23])[cH:21][cH:20]2)[CH2:11][CH2:12]1

Participants

5

Reactant 4

HCID 312Chloride3×HCID 97411,3-DifluorobenzeneHCID 1009501-Acetylpiperidine-4-carbonyl chlorideHCID 104727Aluminum Cation

Product 1

HCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

Sources & evidence

ORD record
ord-18bacdebfb1a40d3b7d63f1bf3707221
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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