Bromomethylcyclopropane → HCID 68538593, compound

HRID 1992460Notes

Reaction equation

HRID 1992460 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16]([C:21]([N:23]2[CH2:28][CH2:27][N:26]([S:29]([CH3:32])(=[O:31])=[O:30])[CH2:25][CH2:24]2)=[O:22])=[CH:15]3)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[CH:33]1([CH2:36]Br)[CH2:35][CH2:34]1>>[CH:33]1([CH2:36][N:17]2[C:18]3[C:14](=[CH:13][C:12]([C:10]([N:7]4[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]4)=[O:11])=[CH:20][CH:19]=3)[CH:15]=[C:16]2[C:21]([N:23]2[CH2:24][CH2:25][N:26]([S:29]([CH3:32])(=[O:30])=[O:31])[CH2:27][CH2:28]2)=[O:22])[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 68538245[5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone

Product 1

HCID 68538593HCID 68538593, compoundYield 54%

Procedure

The title compound was synthesized in analogy to example 3, from [5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone (example 1) and cyclopropylmethyl bromide to afford the desired product as a colorless foam (54%). MS (ISP): 516.2 (M+H)+.

Sources & evidence

ORD record
ord-cf51a52e179a43e3ae3363fd9cfc9688
Source dataset
uspto-grants-2010_01
Patent number
US07648979B2

Reaction notes

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