1-Piperazinecarboxylic acid, ethyl ester → HCID 68535485, compound

HRID 1992489Notes

Reaction equation

HRID 1992489 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16]([C:21]([N:23]2[CH2:28][CH2:27][N:26](S(C)(=O)=O)[CH2:25][CH2:24]2)=[O:22])=[CH:15]3)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[CH2:33]([O:35][C:36](N1CCNCC1)=[O:37])[CH3:34]>>[CH2:33]([O:35][C:36]([N:26]1[CH2:25][CH2:24][N:23]([C:21]([C:16]2[NH:17][C:18]3[C:14]([CH:15]=2)=[CH:13][C:12]([C:10]([N:7]2[CH2:8][CH2:9][N:4]([CH:1]([CH3:2])[CH3:3])[CH2:5][CH2:6]2)=[O:11])=[CH:20][CH:19]=3)=[O:22])[CH2:28][CH2:27]1)=[O:37])[CH3:34]

Participants

3

Reactant 2

HCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 68538245[5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone2×

Product 1

HCID 68535485HCID 68535485, compoundYield 72%

Procedure

The title compound was synthesized in analogy to example 1, from 5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate b) and 1-ethoxycarbonylpiperazine to afford the desired product as a light-brown solid (72%). MS (ISP): 456.3 (M+H)+.

Sources & evidence

ORD record
ord-a993a5cdb9f04a45ba084221c8a512bb
Source dataset
uspto-grants-2010_01
Patent number
US07648979B2

Reaction notes

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