反应详情

1,1,1-Trifluoro-methanesulfonic acid 6-methoxy-[1,5]naphthyridin-4-yl ester (20 g, 65 mmol) was dissolved in DMF and treated with triethylamine (12 mL, 84 mmol) and DL-3-pyrrolidinol (7.4 g , 84 mmol.) The reaction mixture was stirred overnight at room temperature. The resulting reaction mixture was diluted with water (200 mL) and stirred for 1 h. The resulting precipitate was filtered off, washed with diethyl ether, and air dried to afford the title compound: LC-MS m/z 246 (M+H)+

1. customThe resulting reaction mixture
2. stirringstirred for 1 h
3. filtrationThe resulting precipitate was filtered off
4. washwashed with diethyl ether, and air
5. customdried