Ethyl trifluoroacetate → HCID 58955131, compound

HRID 1992520Notes

Reaction equation

HRID 1992520 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[N:13]1[CH2:17][CH2:16][CH:15]([NH:18][CH2:19][CH2:20][NH2:21])[CH2:14]1.[F:22][C:23]([F:30])([F:29])[C:24](OCC)=[O:25]>C1COCC1>[F:22][C:23]([F:30])([F:29])[C:24]([NH:21][CH2:20][CH2:19][NH:18][CH:15]1[CH2:16][CH2:17][N:13]([C:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[N:4]=3)[N:9]=[CH:8][CH:7]=2)[CH2:14]1)=[O:25]

Participants

4

Reactant 2

HCID 9794Ethyl trifluoroacetateHCID 58955137HCID 58955137, compound

Product 1

HCID 58955131HCID 58955131, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of N1-[1-(6-Methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-ethane-1,2-diamine (1.3 g, 4.53 mmol) in THF (50 mL) at 0° C. was slowly added ethyl trifluoroacetate (1.19 mL, 4.53 mmol). The solution was stirred for 1.5 h and concentrated. The resulting solid was used without further purification (1.73 g, quantitive): LC/MS m/z 384 (M+H)+.

Workup

  1. customat 0° C.
  2. concentrationconcentrated
  3. customThe resulting solid was used without further purification (1.73 g, quantitive)

Sources & evidence

ORD record
ord-a611f759806849b2b09211c40c1d10d5
Source dataset
uspto-grants-2010_01
Patent number
US07648984B2

Reaction notes

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