Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

1,1-dimethylethyl [2-({1-[6-(methyloxy)-1,5-naphthyridin-4-yl]-3-pyrrolidinyl}sulfonyl)ethyl]carbamate (150 mg, 0.34 mmol) was dissolved in a minimum amount of chloroform and treated with 4N HCl in dioxane (2 mL). After stirring 2 h, the reaction mixture was concentrated to dryness and azeotroped with toluene to afford HCl salt of the title compound as a yellow solid which was used without further purification (100 mg, 88%): LC/MS m/z 337 (M+H)+.

Provenance & Evidence