Hydrochloric Acid → Hydrochloric Acid

HRID 1992528Notes

Reaction equation

HRID 1992528 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[N:13]1[CH2:17][CH2:16][CH:15]([S:18]([CH2:21][CH2:22][NH:23]C(=O)OC(C)(C)C)(=[O:20])=[O:19])[CH2:14]1.[ClH:31]>C(Cl)(Cl)Cl.O1CCOCC1>[ClH:31].[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[N:13]1[CH2:17][CH2:16][CH:15]([S:18]([CH2:21][CH2:22][NH2:23])(=[O:20])=[O:19])[CH2:14]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 58955139HCID 58955139, compound

Product 2

HCID 313Hydrochloric AcidHCID 58955140HCID 58955140, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 312751,4-DioxaneSolvent

Procedure

1,1-dimethylethyl [2-({1-[6-(methyloxy)-1,5-naphthyridin-4-yl]-3-pyrrolidinyl}sulfonyl)ethyl]carbamate (150 mg, 0.34 mmol) was dissolved in a minimum amount of chloroform and treated with 4N HCl in dioxane (2 mL). After stirring 2 h, the reaction mixture was concentrated to dryness and azeotroped with toluene to afford HCl salt of the title compound as a yellow solid which was used without further purification (100 mg, 88%): LC/MS m/z 337 (M+H)+.

Workup

  1. concentrationthe reaction mixture was concentrated to dryness
  2. customazeotroped with toluene

Sources & evidence

ORD record
ord-f602de71f68b44358b50ee727d049b5b
Source dataset
uspto-grants-2010_01
Patent number
US07648984B2

Reaction notes

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