Hydrogen Bromide → Carvedilol HBr

HRID 1992563Notes

Reaction equation

HRID 1992563 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][NH:12][CH2:13][CH:14]([OH:30])[CH2:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[NH:29][C:28]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:22]=12.[BrH:31]>C(O)CC.O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][NH:12][CH2:13][CH:14]([OH:30])[CH2:15][O:16][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[NH:29][C:28]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:22]=12.[BrH:31]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 2585Carvedilol

Product 1

HCID 9957094Carvedilol HBr

Reagents, catalysts & solvents 1

HCID 22595341Propanol waterSolvent

Procedure

Carvedilol free base is dissolved in n-propanol/water (95:5), and stoichiometric hydrobromic acid is added. The solution is cooled, and crystallization ensues. The product is filtered, washed with process solvent, and dried.

Workup

  1. temperatureThe solution is cooled
  2. customcrystallization ensues
  3. filtrationThe product is filtered
  4. washwashed with process solvent
  5. customdried

Sources & evidence

ORD record
ord-9d2f91e37da04647b5b4b0a1299ec422
Source dataset
uspto-grants-2010_01
Patent number
US07649010B2

Reaction notes

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