反应详情

Carvedilol free base is dissolved in a solvent (dichloromethane, isopropyl acetate, and acetonitrile have been used) and anhydrous HBr is added (HBr in acetic acid or gaseous HBr). The solution is cooled, and crystallization ensues. The product is filtered, washed with process solvent, and dried.

1. temperatureThe solution is cooled
2. customcrystallization ensues
3. filtrationThe product is filtered
4. washwashed with process solvent
5. customdried