反应详情

温度

0 °C

To a solution of 7-bromo-4-chloro-3-nitroquinoline (10.00 g, 34.78 mmol) in dichloromethane (140 mL) was added triethylamine (10.2 mL, 73.1 mmol). The solution was cooled to 0° C., and 3-amino-1-butanol (2.80 mL, 36.5 mmol) was added. The solution was stirred overnight at ambient temperature and then filtered to collect a precipitate. The precipitate was washed with dichloromethane and water. The filtrate was washed with saturated aqueous sodium bicarbonate and then added to the precipitate. The mixture was concentrated under reduced pressure. Methanol and toluene were added several times and removed under reduced pressure. The resulting solid was dried under high vacuum to provide 11.34 g of 3-[(7-bromo-3-nitroquinolin-4-yl)amino]propan-1-ol as a yellow solid.

1. filtrationfiltered
2. customto collect a precipitate
3. washThe precipitate was washed with dichloromethane and water
4. washThe filtrate was washed with saturated aqueous sodium bicarbonate
5. additionadded to the precipitate
6. concentrationThe mixture was concentrated under reduced pressure
7. additionMethanol and toluene were added several times
8. customremoved under reduced pressure
9. customThe resulting solid was dried under high vacuum