Cyclopropanecarbonyl chloride → HCID 59130450, compound

HRID 1992623Notes

Reaction equation

[NH2:1][O:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[C:19]2[C:18]3[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=3[N:12]=[C:11]([NH2:20])[C:10]=2[N:9]=[C:8]1[CH2:21][O:22][CH2:23][CH3:24].[CH:25]1([C:28](Cl)=[O:29])[CH2:27][CH2:26]1>>[NH2:20][C:11]1[C:10]2[N:9]=[C:8]([CH2:21][O:22][CH2:23][CH3:24])[N:7]([CH2:6][CH2:5][CH2:4][CH2:3][O:2][NH:1][C:28]([CH:25]3[CH2:27][CH2:26]3)=[O:29])[C:19]=2[C:18]2[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=2[N:12]=1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 68539852HCID 68539852, compound

Product 1

HCID 59130450HCID 59130450, compound

Procedure

The method described in Example 3 can be used to treat 1-[4-(aminooxy)butyl]-2-(ethoxymethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-4-amine with cyclopropanecarbonyl chloride to provide N-{4-[4-amino-2-(ethoxymethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-1-yl]butoxy}cyclopropanecarboxamide.

Sources & evidence

ORD record: ord-bcd548f34eb144e08f3bab8a6ba90598
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07648997B2

Reaction notes

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