Hydrogen Bromide → Bupropion

HRID 1992690Notes

Reaction equation

[CH3:1][CH:2]([NH:12][C:13]([CH3:16])([CH3:15])[CH3:14])[C:3]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([Cl:11])[CH:10]=1)=[O:4].Cl.Br>>[CH3:1][CH:2]([NH:12][C:13]([CH3:14])([CH3:16])[CH3:15])[C:3]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([Cl:11])[CH:10]=1)=[O:4]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 62884Bupropion Hydrochloride

Product 1

HCID 444Bupropion

Procedure

Bupropion HCl was replaced with HBr and adjusted to obtain same amount Bupropion base.

Sources & evidence

ORD record: ord-a9de9c8d35a94391b2c39510983731c5
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07649019B2

Reaction notes

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