Thionyl Chloride → 1-Methylpiperidine-4-carbonyl chloride

HRID 1992702Notes

Reaction equation

HRID 1992702 reaction equation
Cl.[CH3:2][N:3]1[CH2:8][CH2:7][CH:6]([C:9]([OH:11])=O)[CH2:5][CH2:4]1.S(Cl)([Cl:14])=O>>[CH3:2][N:3]1[CH2:8][CH2:7][CH:6]([C:9]([Cl:14])=[O:11])[CH2:5][CH2:4]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27600434-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1)

Product 1

HCID 4365031-Methylpiperidine-4-carbonyl chloride

Procedure

1-Methylpiperidine-4-carboxylic acid hydrochloride salt 10 g (55.7 mmol) was added to thionyl chloride (25 ml) and resulting mixture stirred at room temperature until the solid dissolved completely. The reaction mixture was stirred for another 20 minutes and concentrated. The product was used for the next step without further purification.

Workup

  1. customresulting mixture
  2. dissolutiondissolved completely
  3. stirringThe reaction mixture was stirred for another 20 minutes
  4. concentrationconcentrated
  5. customThe product was used for the next step without further purification

Sources & evidence

ORD record
ord-8e74db57073b4db6900c551d662b43e0
Source dataset
uspto-grants-2010_01
Patent number
US07649092B2

Reaction notes

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