HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-Methylpiperidine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Piperidinecarboxylic acid, 1-methyl-, hydrochloride (1:1) | HCID 2760043 | — |
| Product | 1-Methylpiperidine-4-carbonyl chloride | HCID 436503 | — |
Reaction Steps
1-Methylpiperidine-4-carboxylic acid hydrochloride salt 10 g (55.7 mmol) was added to thionyl chloride (25 ml) and resulting mixture stirred at room temperature until the solid dissolved completely. The reaction mixture was stirred for another 20 minutes and concentrated. The product was used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07649092B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-8e74db57073b4db6900c551d662b43e0 |
| Source note | uspto-grants-2010_01 |