HCID 54061615, compound → HCID 45099860, compound

HRID 1992715Notes

Reaction equation

HRID 1992715 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C@@H:15]2[CH2:19][CH2:18][CH2:17][N:16]2[CH3:20])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C1COCC1.[Pd]>[CH3:20][N:16]1[CH2:17][CH2:18][CH2:19][C@H:15]1[CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 54061615HCID 54061615, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 45099860HCID 45099860, compoundYield 94.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (S)-1-benzyl-4-[(1-methylpyrrolidin-2-yl)methyl]piperazine 0.71 g (2.61 mmol) in 40 ml THF was added 10% Pd/C 0.4 g and exposed to 1 atm hydrogen overnight. The reaction mixture was filtered. The filtrate was concentrated to give 0.450 g of desired product in 94% yield.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-fc62e8ef0fd6485d9208c1f314aaecc4
Source dataset
uspto-grants-2010_01
Patent number
US07649092B2

Reaction notes

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