反应详情

To a solution of mechlorethamine (4 g, 25.6 mmol) and benzyl cyanide (4 g, 34.2 mmol) in toluene (25 ml) was added sodium amide (2 g, 51.2 mmol) at 40-50° C. in portions for 1 hour. The reaction mixture was heated to reflux about 2 hours after the addition. The reaction mixture was cooled to room temperature and washed with saturated sodium bicarbonate solution and brine, dried over sodium sulfate and concentrated. The residue was applied to flash column chromatography using methylene chloride and methanol (100:5) as eluents to give 3 g of desired product.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux about 2 hours
3. additionafter the addition
4. washwashed with saturated sodium bicarbonate solution and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated