N-methyl-2-pyrrolidone → HCID 72988237, compound

HRID 1992755Notes

Reaction equation

HRID 1992755 reaction equation
[CH3:1][O:2][CH:3]([O:20][CH3:21])[CH2:4][CH:5]1[C:9](=[O:10])[CH2:8][CH2:7][CH:6]1[CH:11](C(OC)=O)[C:12]([O:14][CH3:15])=[O:13].CN1C(=O)CCC1>O>[CH3:1][O:2][CH:3]([O:20][CH3:21])[CH2:4][CH:5]1[C:9](=[O:10])[CH2:8][CH2:7][CH:6]1[CH2:11][C:12]([O:14][CH3:15])=[O:13]

Participants

4

Reactant 2

HCID 13387N-methyl-2-pyrrolidoneHCID 67423893HCID 67423893, compound

Product 1

HCID 72988237HCID 72988237, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a 3-neck 250 ml round bottom flask equipped with a short path distillation apparatus, a solution of 80.0 g of dimethyl [2-(2,2-dimethoxyethyl)-3-oxocyclopentyl]malonate and 63.0 g NMP was heated to 160° C. The solution was then charged with water until the reaction was complete. Upon completion of the reaction, distillation under vacuum (b.p.=140-145° C. at 1 mbar) of the reaction medium allowed to recover directly the purified title compound with a yield of 81%.

Workup

  1. customIn a 3-neck 250 ml round bottom flask equipped with a short path distillation apparatus
  2. customUpon completion of the reaction, distillation under vacuum (b.p.=140-145° C. at 1 mbar) of the reaction medium
  3. customto recover directly the
  4. custompurified title compound with a yield of 81%

Sources & evidence

ORD record
ord-19597ef50be54893ac27967911088bd7
Source dataset
uspto-grants-2010_01
Patent number
US07649107B2

Reaction notes

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