Hydrochloric Acid → HCID 67019495, compound

HRID 1992807Notes

Reaction equation

HRID 1992807 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:20]=[CH:19][C:8]([CH2:9][NH:10][NH:11]C(OC(C)(C)C)=O)=[CH:7][CH:6]=1)=[O:4].[ClH:21]>>[ClH:21].[NH:10]([CH2:9][C:8]1[CH:19]=[CH:20][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=1)[NH2:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 16732764HCID 16732764, compound

Product 1

HCID 67019495HCID 67019495, compound

Procedure

To the intermediate from step C (1.89 g, 6.75 mmol) was added HCl (4.0 M in dioxane, 100 mL). After stirring the reaction for 16 hours it was concentrated in vacuo to give a white powder. 1H NMR (CD3OD, 500 MHz): 8.09 (d, J=8.0 Hz, 2H), 7.57 (d, J=8.0 Hz, 2H), 4.21 (s, 2H), 3.93 (s, 3H). LC-MS=0.77; (M+H)=181.

Workup

  1. customthe reaction for 16 hours it
  2. concentrationwas concentrated in vacuo
  3. customto give a white powder

Sources & evidence

ORD record
ord-88d06e02e46847e7bf82bb3851d964ab
Source dataset
uspto-grants-2010_01
Patent number
US07649009B2

Reaction notes

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