HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 6,6,6-Trifluoro-3-{[3-(methyloxy)phenyl]methyl}hexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 6,6,6-trifluoro-3-{[3-(methyloxy)phenyl]methyl}hexanoate | HCID 68537268 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6,6,6-Trifluoro-3-{[3-(methyloxy)phenyl]methyl}hexanoic acid | HCID 68539848 | 98% |
Reaction Steps
Ethyl ester (119) (1.75 g, 5.50 mmol) was saponified with 1 N NaOH in THF and EtOH to give 1.56 g (98%) of the title compound (120) as a yellow oil. 1H NMR (400 MHz, CDCl3): δ 1.60-1.70 (m, 2H), 2.05-2.40 (m, 5H), 2.55-2.70 (m, 2H), 3.80 (s, 3H), 6.70-6.74 (m, 1H), 6.74-6.80 (m, 2H), 7.21 (t, J=7.9 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07649093B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-90be3f3a830a4f70bc4f6958a1007aad |
| Source note | uspto-grants-2010_01 |