反应详情

Ethyl ester (119) (1.75 g, 5.50 mmol) was saponified with 1 N NaOH in THF and EtOH to give 1.56 g (98%) of the title compound (120) as a yellow oil. 1H NMR (400 MHz, CDCl3): δ 1.60-1.70 (m, 2H), 2.05-2.40 (m, 5H), 2.55-2.70 (m, 2H), 3.80 (s, 3H), 6.70-6.74 (m, 1H), 6.74-6.80 (m, 2H), 7.21 (t, J=7.9 Hz, 1H).