Hydrochloric Acid → HCID 57295838, compound

Participants

Reaction Steps

1-{[(Methyloxy)methyl]oxy}-2-phenyl-3-(trifluoromethyl)naphthalene (181) (0.23 g, 0.68 mmol) was treated with 4.0M HCl in dioxane at room temperature to give 0.19 g (97%) of the title compound (182) as a colorless oil. 1H NMR (400 MHz, CDCl3): δ 5.40 (s, 1H), 7.39 (d, J=7.1 Hz, 2H), 7.48-7.58 (m, 3H), 7.58-7.66 (m, 2H), 7.86 (s, 1H), 7.88-7.94 (m, 1H), 8.24-8.30 (m, 1H). LCMS (APCI): m/z 287 (M−H)−.

Provenance & Evidence