Hydrochloric Acid → HCID 57295838, compound

HRID 1992948Notes

Reaction equation

HRID 1992948 reaction equation
COC[O:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[C:7]([C:15]([F:18])([F:17])[F:16])[C:6]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.Cl>O1CCOCC1>[C:19]1([C:6]2[C:7]([C:15]([F:17])([F:18])[F:16])=[CH:8][C:9]3[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:5]=2[OH:4])[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68537301HCID 68537301, compound

Product 1

HCID 57295838HCID 57295838, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1-{[(Methyloxy)methyl]oxy}-2-phenyl-3-(trifluoromethyl)naphthalene (181) (0.23 g, 0.68 mmol) was treated with 4.0M HCl in dioxane at room temperature to give 0.19 g (97%) of the title compound (182) as a colorless oil. 1H NMR (400 MHz, CDCl3): δ 5.40 (s, 1H), 7.39 (d, J=7.1 Hz, 2H), 7.48-7.58 (m, 3H), 7.58-7.66 (m, 2H), 7.86 (s, 1H), 7.88-7.94 (m, 1H), 8.24-8.30 (m, 1H). LCMS (APCI): m/z 287 (M−H)−.

Sources & evidence

ORD record
ord-d0ecac6f704b4a4cbfc8fb088b909f90
Source dataset
uspto-grants-2010_01
Patent number
US07649093B2

Reaction notes

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