HCID 86616676, compound → HCID 68536290, compound

HRID 1992996Notes

Reaction equation

HRID 1992996 reaction equation
[CH3:1][C:2]1[C:3]([C:36]2[CH:41]=[CH:40][C:39]([O:42][CH2:43][C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)=[CH:38][CH:37]=2)=[C:4]([O:22][C:23]2[CH:28]=[CH:27][C:26](/[CH:29]=[CH:30]/[C:31]([O:33]CC)=[O:32])=[CH:25][CH:24]=2)[C:5]2[C:10]([C:11]=1[O:12][CH3:13])=[CH:9][C:8]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[CH:7][CH:6]=2>C(Cl)(Cl)Cl.CO>[CH3:1][C:2]1[C:3]([C:36]2[CH:37]=[CH:38][C:39]([O:42][CH2:43][C:44]3[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=3)=[CH:40][CH:41]=2)=[C:4]([O:22][C:23]2[CH:28]=[CH:27][C:26](/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32])=[CH:25][CH:24]=2)[C:5]2[C:10]([C:11]=1[O:12][CH3:13])=[CH:9][C:8]([O:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[CH:7][CH:6]=2

Participants

3

Reactant 1

HCID 86616676HCID 86616676, compound

Product 1

HCID 68536290HCID 68536290, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Synthesized in a manner similar to Example 46 (Step 7) using ethyl (2E)-3-{4-[(3-methyl-4-(methyloxy)-6-[(phenylmethyl)oxy]-2-{4-[(phenylmethyl)oxy]phenyl}-1-naphthalenyl)oxy]phenyl}-2-propenoate (257). 1H NMR (CDCl3, 300 MHz) δ 7.65 (d, J=9.1 Hz, 1H), 7.57 (d, J=16.0 Hz, 1H), 7.45-7.18 (m, 1H), 7.07 (dd, J=9.0, 2.5 Hz, 1H), 6.96 (d, J=8.5 Hz, 2H), 6.80 (d, J=8.7 Hz, 2H) 6.53 (d, J=8.6 Hz, 2H), 6.53 (d, J=8.6 Hz, 2H), 6.16 (d, J=16.0 Hz, 1H), 5.16 (s, 2H), 4.95 (s, 2H), 3.81 (s, 3H), 2.12 (s, 3H). LRMS (ESI) m/z 621 (M−1)−. TLC (90:10; CHCl3/MeOH): Rf=0.44.

Workup

  1. customSynthesized in a manner similar to Example 46 (Step 7)

Sources & evidence

ORD record
ord-aed07477d0d847b4badbb2fb625ffb3d
Source dataset
uspto-grants-2010_01
Patent number
US07649093B2

Reaction notes

Loading…