HCID 86616677, compound → HCID 68534826, compound

HRID 1992999Notes

Reaction equation

HRID 1992999 reaction equation
[CH3:1][C:2]1[C:3]([C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)=[C:4]([O:14][C:15]2[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]([O:25]CC)=[O:24])=[CH:17][CH:16]=2)[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2>C(Cl)(Cl)Cl.CO>[CH3:1][C:2]1[C:3]([C:28]2[CH:29]=[CH:30][C:31]([O:34][CH3:35])=[CH:32][CH:33]=2)=[C:4]([O:14][C:15]2[CH:16]=[CH:17][C:18](/[CH:21]=[CH:22]/[C:23]([OH:25])=[O:24])=[CH:19][CH:20]=2)[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12][CH3:13])[CH:6]=2

Participants

3

Reactant 1

HCID 86616677HCID 86616677, compound

Product 1

HCID 68534826HCID 68534826, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Synthesized in a manner similar to Example 46 (Step 7) using ethyl (2E)-3-[4-({3-methyl-7-(methyloxy)-2-[4-(methyloxy)phenyl]-1-naphthalenyl}oxy)phenyl]-2-propenoate (265). 1H NMR (CDCl3, 400 MHz) δ 7.74 (d, J=9.0 Hz, 1H), 7.64 (d, J=15.9 Hz, 1H), 7.60 (s, 1H), 7.29 (d, J=8.8 Hz, 2H), 7.14 (dd, J=8.7, 2.4 Hz, 1H), 7.06-7.04 (m, 3H), 6.81 (d, J=8.7 Hz, 2H), 6.63 (d, J=8.7 Hz, 2H), 6.24 (d, J=15.9 Hz, 1H), 3.78 (s, 3H), 3.74 (s, 3H), 2.24 (s, 3H). TLC (90:10; CHCl3/MeOH): Rf=0.26.

Workup

  1. customSynthesized in a manner similar to Example 46 (Step 7)

Sources & evidence

ORD record
ord-8d1c7a88d6ee4e03886ed964a4b190ee
Source dataset
uspto-grants-2010_01
Patent number
US07649093B2

Reaction notes

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