HCID 68534826, compound → HCID 11632964, compound

HRID 1993000Notes

Reaction equation

HRID 1993000 reaction equation
[CH3:1][C:2]1[C:3]([C:26]2[CH:31]=[CH:30][C:29]([O:32]C)=[CH:28][CH:27]=2)=[C:4]([O:14][C:15]2[CH:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]([OH:25])=[O:24])=[CH:17][CH:16]=2)[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([O:12]C)[CH:6]=2>C(Cl)(Cl)Cl.CO>[OH:12][C:7]1[CH:6]=[C:5]2[C:10]([CH:11]=[C:2]([CH3:1])[C:3]([C:26]3[CH:27]=[CH:28][C:29]([OH:32])=[CH:30][CH:31]=3)=[C:4]2[O:14][C:15]2[CH:16]=[CH:17][C:18](/[CH:21]=[CH:22]/[C:23]([OH:25])=[O:24])=[CH:19][CH:20]=2)=[CH:9][CH:8]=1

Participants

3

Reactant 1

HCID 68534826HCID 68534826, compound

Product 1

HCID 11632964HCID 11632964, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Synthesized in a manner similar to Example 46 (Step 8) using (2E)-3-[4-({3-methyl-7-(methyloxy)-2-[4-(methyloxy)phenyl]-1-naphthalenyl}oxy)phenyl]-2-propenoic acid (266). 1H NMR (CD3OD, 400 MHz) δ 7.71 (d, J=8.6 Hz, 1H), 7.58 (s, 1H), 7.49 (d, J=15.5 Hz, 1H), 7.34 (d, J=8.4 Hz, 2H), 7.04 (dd, J=8.7, 2.0 Hz, 1H), 7.00 (s, 1H), 6.94 (d, J=8.5 Hz, 2H), 6.68 (d, J=8.4 Hz, 2H), 6.58 (d, J=8.4 Hz, 2H), 6.27 (d, J=15.2 Hz, 1H), 2.19 (s, 3H). TLC (90:10; CHCl3/MeOH): Rf=0.19.

Workup

  1. customSynthesized in a manner similar to Example 46 (Step 8)

Sources & evidence

ORD record
ord-da3a4b3110a34e5aade2e20c3d9fb95f
Source dataset
uspto-grants-2010_01
Patent number
US07649093B2

Reaction notes

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