反应详情

温度

60 °C

NBS (1.46 g, 8.23 mmol) was added to a solution of 31.1 (1.59 g, 7.48 mmol) in carbon tetrachloride (8 mL). The reaction was stirred at 60° C. overnight and filtered to remove succinimide. The filtrate was concentrated in vacuo and purified via radial chromatography (15% diethyl ether in hexanes) to yield 0.65 g (25%) of 2-(2-methyl-benzyloxy)-5-bromotoluene (31.2). LC/MSD m/e: 314.2 (M+Na).

1. filtrationfiltered
2. customto remove succinimide
3. concentrationThe filtrate was concentrated in vacuo
4. custompurified via radial chromatography (15% diethyl ether in hexanes)