HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1993046Generated: October 26, 2026
N-bromobutanimide → 4-Bromo-2-methyl-1-((2-methylbenzyl)oxy)benzene
https://huagongshe.com/reaction/1993046
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 1-Methyl-2-((2-methylphenoxy)methyl)benzene | HCID 52146955 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 4-Bromo-2-methyl-1-((2-methylbenzyl)oxy)benzene | HCID 59132749 | 29.8% |
Reaction Steps
NBS (1.46 g, 8.23 mmol) was added to a solution of 31.1 (1.59 g, 7.48 mmol) in carbon tetrachloride (8 mL). The reaction was stirred at 60° C. overnight and filtered to remove succinimide. The filtrate was concentrated in vacuo and purified via radial chromatography (15% diethyl ether in hexanes) to yield 0.65 g (25%) of 2-(2-methyl-benzyloxy)-5-bromotoluene (31.2). LC/MSD m/e: 314.2 (M+Na).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07649110B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-e27afddfdb2c452eb9452a90b4d6e009 |
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| Source note | uspto-grants-2010_01 |
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