2,5-Dibromopyridine → 4-(5-bromopyridin-2-yl)benzaldehyde

HRID 1993095Notes

Reaction equation

HRID 1993095 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1)=[O:2].Br[C:13]1[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][N:14]=1>>[Br:19][C:16]1[CH:17]=[CH:18][C:13]([C:6]2[CH:7]=[CH:8][C:3]([CH:1]=[O:2])=[CH:4][CH:5]=2)=[N:14][CH:15]=1

Participants

3

Reactant 2

HCID 693532,5-DibromopyridineHCID 5910734-Formylphenylboronic Acid

Product 1

HCID 118497144-(5-bromopyridin-2-yl)benzaldehyde

Procedure

Scheme 40, Example 1, illustrates the coupling reaction of 4-formylphenylboronic acid 40.1 with 2,5-dibromopyridine 40.11, using the procedure described above, to afford 4-(5-bromo-2-pyridyl)benzaldehyde 40.12. This compound is then coupled, as described above, with a dialkyl phosphite 40.4, to afford the pyridyl phosphonate 40.13.

Sources & evidence

ORD record
ord-3acdece82eed400ba6d8d48bbdcb1e71
Source dataset
uspto-grants-2010_01
Patent number
US07649015B2

Reaction notes

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