HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → (1-Amino-2-methylpropan-2-yl)phosphonic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Bromotrimethylsilane | HCID 76113 | — |
| Reactant | Dietyl(2-amino-1,1-dimethyl-ethyl)phosphonate | HCID 58928684 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1-Amino-2-methylpropan-2-yl)phosphonic acid | HCID 281240 | — |
Reaction Steps
A solution of CH3CN (30 mL) of crude 6 (2.5 g) was cooled to 0° C., and treated with TMSBr (8 g, 52 mmol) for 5 hr. The reaction mixture was stirred with methanol for 1.5 hr at room temperature, concentrated, recharged with methanol, concentrated to dryness to give crude 7 which was used for next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07649015B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-450613276df24dbeb25860721c6e1fa6 |
| Source note | uspto-grants-2010_01 |