Trifluoroacetic acid → HCID 68613625, compound

HRID 1993125Notes

Reaction equation

HRID 1993125 reaction equation
C([O:5][C:6]1[CH:37]=[CH:36][C:9]([CH2:10][CH:11]2[NH:20][C:19](=[O:21])[NH:18][CH:17]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([O:29]C(C)(C)C)=[CH:25][CH:24]=3)[CH:16]3[CH:12]2[O:13]C(C)(C)[O:15]3)=[CH:8][CH:7]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[OH:13][CH:12]1[CH:16]([OH:15])[CH:17]([CH2:22][C:23]2[CH:24]=[CH:25][C:26]([OH:29])=[CH:27][CH:28]=2)[NH:18][C:19](=[O:21])[NH:20][CH:11]1[CH2:10][C:9]1[CH:8]=[CH:7][C:6]([OH:5])=[CH:37][CH:36]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68613817HCID 68613817, compound

Product 1

HCID 68613625HCID 68613625, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Cyclic Urea 2.8 (0.4 g, 0.78 mmol) was dissolved in dichloromethane (3 mL) and treated with TFA (1 mL). The mixture was stirred at room temperature for 2 h upon which time a white solid precipitated. 2 drops of water and methanol (2 mL) were added and the homogeneous solution was stirred for 1 h and concentrated under reduced pressure. The crude solid, 2.9, was dried overnight and then used without further purification.

Workup

  1. customprecipitated
  2. addition2 drops of water and methanol (2 mL) were added
  3. stirringthe homogeneous solution was stirred for 1 h
  4. concentrationconcentrated under reduced pressure
  5. customThe crude solid, 2.9, was dried overnight
  6. customused without further purification

Sources & evidence

ORD record
ord-39aa2434ddda44c09fea1b52355ab1db
Source dataset
uspto-grants-2010_01
Patent number
US07649015B2

Reaction notes

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