Cyclobutanecarboxylic acid → 8-Chloro-3-cyclobutylimidazo[1,5-a]pyrazine

HRID 1993151Notes

Reaction equation

HRID 1993151 reaction equation
[Cl:1][C:2]1[C:3]2[N:4]([C:8]([C@H:11]3[CH2:16][CH2:15][C@H:14](C(OC)=O)CC3)=[N:9][CH:10]=2)[CH:5]=[CH:6][N:7]=1.ClC1C(CNC([C@H]2CC[C@H](C(OC)=O)CC2)=O)=NC=CN=1.C1(C(O)=O)CCC1>>[Cl:1][C:2]1[C:3]2[N:4]([C:8]([CH:11]3[CH2:16][CH2:15][CH2:14]3)=[N:9][CH:10]=2)[CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 3

HCID 19494Cyclobutanecarboxylic acidHCID 178501055HCID 178501055, compoundHCID 178501155HCID 178501155, compound

Product 1

HCID 426093638-Chloro-3-cyclobutylimidazo[1,5-a]pyrazine

Procedure

This compound was prepared using procedures analogous to that described for trans-methyl 4-(8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclohexanecarboxylate and its precursor trans-methyl 4-({[(3-chloropyrazin-2-yl)methyl]amino}carbonyl)cyclohexanecarboxylate, using cyclobutanecarboxylic acid in place of 4-(methoxycarbonyl)cyclohexanecarboxylic acid.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-31efa0ddec844a1a8f8c54dad5ddc15f
Source dataset
uspto-grants-2010_01
Patent number
US07651687B2

Reaction notes

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