反应详情

温度

170 °C

A mixture of 3-(3-fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine (Step 1, 0.60 g, 2.0 mmol) and pyridine hydrochloride (3 g) was heated in an oil bath at 170° C. for 8 h. The sublimed pyridine hydrochloride on the top of the reaction flask was removed, and the residue (0.65 g) was used in the next step without further purification. MS (ESI pos. ion) m/z: 283.1 (M+H). Calc'd Exact Mass for C16H11FN2O2: 282.27.

1. customThe sublimed pyridine hydrochloride on the top of the reaction flask was removed
2. customthe residue (0.65 g) was used in the next step without further purification