HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1993368Generated: October 30, 2026
Pyridinium chloride → 2-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol
https://huagongshe.com/reaction/1993368
Participants
| Role | Name | HCID | Charge |
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| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 3-(3-Fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine | HCID 57445400 | — |
| Product | 2-Fluoro-4-(6-phenoxy-pyridazin-3-yl)-phenol | HCID 136070705 | — |
Reaction Steps
A mixture of 3-(3-fluoro-4-methoxy-phenyl)-6-phenoxy-pyridazine (Step 1, 0.60 g, 2.0 mmol) and pyridine hydrochloride (3 g) was heated in an oil bath at 170° C. for 8 h. The sublimed pyridine hydrochloride on the top of the reaction flask was removed, and the residue (0.65 g) was used in the next step without further purification. MS (ESI pos. ion) m/z: 283.1 (M+H). Calc'd Exact Mass for C16H11FN2O2: 282.27.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07652009B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-0e6be287f8ed412a89bbf6605cbdc0f7 |
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| Source note | uspto-grants-2010_01 |
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