(1,1'-Biphenyl)-2-carboxaldehyde → 6-(4-Biphenyl-2-ylmethyl-piperazin-1-yl)-3H-pyrimidin-4-one

HRID 1993439노트

반응식

HRID 1993439 반응식
[N:1]1([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:14]1([C:20]2[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=2[CH:22]=O)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:20]1([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22][N:4]1[CH2:5][CH2:6][N:1]([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 121052(1,1'-Biphenyl)-2-carboxaldehydeHCID 1361025406-piperazin-1-yl-3H-pyrimidin-4-one2회

생성물 1

HCID 1361025736-(4-Biphenyl-2-ylmethyl-piperazin-1-yl)-3H-pyrimidin-4-one

실험 절차

6-(4-Biphenyl-2-ylmethyl-piperazin-1-yl)-3H-pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 2-phenylbenzaldehyde (available from Aldrich). 1H NMR (400 MHz, CDCl3) δ 2.36-2.39 (m, 4H), 3.43-3.48 (m, 6H), 5.32 (s, 1H), 7.25-7.40 (m, 8H), 7.80 (s, 1H), 12.20 (br s, 1H). Mass spectrum (ES) MH+=347.

출처 및 근거

ORD 기록
ord-7325a087abf6407cb0c4196372c054b7
출처 데이터셋
uspto-grants-2010_01
특허 번호
US07652013B2

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