1,3-Benzodioxole-4-carboxaldehyde → HCID 136102558, compound

HRID 1993440Notes

Reaction equation

HRID 1993440 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:14]1[O:24][C:23]2[C:16](=[C:17]([CH:20]=[CH:21][CH:22]=2)[CH:18]=O)[O:15]1>>[O:24]1[C:23]2[CH:22]=[CH:21][CH:20]=[C:17]([CH2:18][N:4]3[CH2:5][CH2:6][N:1]([C:7]4[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=4)[CH2:2][CH2:3]3)[C:16]=2[O:15][CH2:14]1

Participants

3

Reactant 2

HCID 822641,3-Benzodioxole-4-carboxaldehydeHCID 1361025406-piperazin-1-yl-3H-pyrimidin-4-one2×

Product 1

HCID 136102558HCID 136102558, compound

Procedure

6-(4-Benzo[1,3]dioxol-4-ylmethyl-piperazin-1-yl)-3H -pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 2,3-(methylenedioxy)benzaldehyde (available from Aldrich). 1H NMR (400 MHz, CDCl3) δ 2.51-2.54 (m, 4H), 3.48-3.58 (m, 6H), 5.35 (s, 1H), 5.95 (s, 2H), 6.74-6.82 (m, 2H), 7.81 (s, 1H). Mass spectrum (ES) MH+=315.

Sources & evidence

ORD record
ord-87d6f8e84355463f90284d2078eda117
Source dataset
uspto-grants-2010_01
Patent number
US07652013B2

Reaction notes

Loading…