3-tert-Butyl-2-hydroxybenzaldehyde → HCID 136102541, compound

HRID 1993444Notes

Reaction equation

HRID 1993444 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:14]([C:18]1[C:19]([OH:26])=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH:21]=O)([CH3:17])([CH3:16])[CH3:15]>>[C:14]([C:18]1[C:19]([OH:26])=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH2:21][N:4]1[CH2:5][CH2:6][N:1]([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:2][CH2:3]1)([CH3:17])([CH3:15])[CH3:16]

Participants

3

Reactant 2

HCID 36786753-tert-Butyl-2-hydroxybenzaldehydeHCID 1361025406-piperazin-1-yl-3H-pyrimidin-4-one2×

Product 1

HCID 136102541HCID 136102541, compound

Procedure

6-[4-(3-tert-Butyl-2-hydroxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 3-tert-butyl-2-hydroxybenzaldehyde (available from Aldrich). 1H NMR (400 MHz, CDCl3) δ 1.40 (s, 9H), 2.58-2.63 (m, 4H), 3.48-3.60 (m, 4H), 3.73 (s, 2H), 5.40 (s, 1H), 6.72-6.76 (m, 1H), 6.84-6.86 (m, 1H), 7.20-7.22 (m, 1H), 7.85 (s,1H), 10.80 (br s, 1H), 12.65 (br s, 1H). Mass spectrum (ES) MH+=343.

Sources & evidence

ORD record
ord-8cf6d2d08fd64dac98e2f1fdb8f535ab
Source dataset
uspto-grants-2010_01
Patent number
US07652013B2

Reaction notes

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