3-tert-Butyl-2-hydroxybenzaldehyde → HCID 136102541, compound

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6-[4-(3-tert-Butyl-2-hydroxy-benzyl)-piperazin-1-yl]-3H-pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 3-tert-butyl-2-hydroxybenzaldehyde (available from Aldrich). 1H NMR (400 MHz, CDCl3) δ 1.40 (s, 9H), 2.58-2.63 (m, 4H), 3.48-3.60 (m, 4H), 3.73 (s, 2H), 5.40 (s, 1H), 6.72-6.76 (m, 1H), 6.84-6.86 (m, 1H), 7.20-7.22 (m, 1H), 7.85 (s,1H), 10.80 (br s, 1H), 12.65 (br s, 1H). Mass spectrum (ES) MH+=343.

Provenance & Evidence