5-Iodosalicylaldehyde → HCID 136102562, compound

HRID 1993454Notes

Reaction equation

HRID 1993454 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[I:14][C:15]1[CH:22]=[C:19]([CH:20]=O)[C:18]([OH:23])=[CH:17][CH:16]=1>>[OH:23][C:18]1[CH:17]=[CH:16][C:15]([I:14])=[CH:22][C:19]=1[CH2:20][N:4]1[CH2:5][CH2:6][N:1]([C:7]2[N:12]=[CH:11][NH:10][C:9](=[O:13])[CH:8]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 2526125-IodosalicylaldehydeHCID 1361025406-piperazin-1-yl-3H-pyrimidin-4-one2×

Product 1

HCID 136102562HCID 136102562, compound

Procedure

6-[4-(2-Hydroxy-5-iodo-benzyl)-piperazin-1-yl]-3H -pyrimidin-4-one was prepared using Procedure B from 6-piperazin-1-yl-3H-pyrimidin-4-one (Intermediate 4) and 5-iodosalicylaldehyde (available from Aldrich). 1H NMR (400 MHz, DMSO-d6) δ 2.42-2.47 (m, 4H), 3.28-3.55 (m, 6H), 5.26 (s, 1H), 6.61-6.63 (m, 1H), 7.38-7.46 (m, 2H), 7.84 (s, 1H), 10.30 (br s, 1H), 11.63 (br s, 1H). Mass spectrum (ES) MH+=413.

Sources & evidence

ORD record
ord-e7b314487bc240acba78862667008672
Source dataset
uspto-grants-2010_01
Patent number
US07652013B2

Reaction notes

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