4-Methylphenyl isocyanate → HCID 58659428, compound

HRID 1993531Notes

Reaction equation

HRID 1993531 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)=[CH:5][CH:4]=1.[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1>C1COCC1>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:25]([NH:24][C:21]3[CH:22]=[CH:23][C:18]([CH3:17])=[CH:19][CH:20]=3)=[O:26])=[CH:14][CH:15]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 693254-Methylphenyl isocyanateHCID 68538580HCID 68538580, compound

Product 1

HCID 58659428HCID 58659428, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is prepared from 4-(6-methoxy-pyridin-3-ylmethyl)-phenylamine (Stage 95.1; 300 mg, 1.40 mmol) and 4-methyl-phenyl-isocyanate (0.35 ml, 2.8 mmol) in THF (11 ml) analogously to Example 89: 1H-NMR (DMSO-d6): 8.68 (s, 2 HN), 8.02 (d, 1H), 7.49 (dd, 1H), 7.33 (d, 2H), 7.29 (d, 2H), 7.09 (d, 2H), 7.03 (d, 2H), 6.70 (d, 1H), 3.79 (2s, 5H), 2.21 (s, 3H).

Sources & evidence

ORD record
ord-f30da918860940ffb3666bc5e696d9c5
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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