4-Ethylphenyl isocyanate → 1-[4-(2-Chloro-pyridin-4-yloxy)-phenyl]-3-(4-ethyl-phenyl)-urea

HRID 1993539Notes

Reaction equation

HRID 1993539 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[CH2:16]([C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1)[CH3:17]>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:25]([NH:24][C:21]3[CH:22]=[CH:23][C:18]([CH2:16][CH3:17])=[CH:19][CH:20]=3)=[O:26])=[CH:11][CH:10]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 900074-Ethylphenyl isocyanateHCID 578334304-(2-Chloro-pyridin-4-yloxy)-phenylamine

Product 1

HCID 586594061-[4-(2-Chloro-pyridin-4-yloxy)-phenyl]-3-(4-ethyl-phenyl)-urea

Procedure

The title compound is prepared as described in Example 102 but using 4-(2-chloro-pyridin-4-yloxy)-phenylamine (Example 105) and 4-ethyl-phenyl-isocyanate. The reaction mixture is stirred for 4 h. The title compound is obtained as a beige solid: ES-MS: 368.0 [M+H]+; single peak at tR=9.85 min (System 2); Rf=0.36 (CH2Cl2/Et2O, 90/10).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-a22c5cf90f554462a52b4a3f7579c385
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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