3-(Trifluoromethyl)phenyl isocyanate → HCID 58659407, compound

HRID 1993544Notes

Reaction equation

HRID 1993544 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH:6]=[CH:5][N:4]=1.[F:19][C:20]([F:31])([F:30])[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([N:27]=[C:28]=[O:29])[CH:22]=1>>[F:19][C:20]([F:30])([F:31])[C:21]1[CH:22]=[C:23]([NH:27][C:28]([NH:16][C:13]2[CH:14]=[CH:15][C:10]([O:9][C:7]3[CH:6]=[CH:5][N:4]=[C:3]([C:2]([F:1])([F:17])[F:18])[CH:8]=3)=[CH:11][CH:12]=2)=[O:29])[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 591345604-{[2-(Trifluoromethyl)pyridin-4-yl]oxy}aniline

Product 1

HCID 58659407HCID 58659407, compound

Procedure

The title compound is prepared as described in Example 102 but using 4-(2-trifluoromethyl-pyridin-4-yloxy)-phenylamine (Example 108) and α,α,α-trifluoro-m-tolyl-isocyanate. The reaction mixture is stirred for 4 h. The title compound is obtained as a white solid: ES-MS: 441.8 [M+H]+; single peak at tR=9.44 min (System 2); Rf=0.38 (CH2Cl2/Et2O, 90/10).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-32b262638d7c4a86b7e8f9a6537830ba
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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