4-Ethylphenyl isocyanate → 1-(4-Ethyl-phenyl)-3-[4-(6-trifluoromethyl-pyrimidin-4-yloxy)-phenyl]-urea

HRID 1993549Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1993549
[C:1]1([CH3:28])[CH:6]=[CH:5][C:4]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[N:21]=[CH:20][N:19]=3)=[CH:13][CH:12]=2)=[O:9])=[CH:3][CH:2]=1.[CH2:29](C1C=CC(N=C=O)=CC=1)C>>[CH2:28]([C:1]1[CH:2]=[CH:3][C:4]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]3[CH:23]=[C:22]([C:24]([F:26])([F:27])[F:25])[N:21]=[CH:20][N:19]=3)=[CH:13][CH:12]=2)=[O:9])=[CH:5][CH:6]=1)[CH3:29]

Komponenten

3

Edukt 2

HCID 900074-Ethylphenyl isocyanateHCID 586593391-p-Tolyl-3-[4-(6-trifluoromethyl-pyrimidin-4-yloxy)-phenyl]-urea

Produkt 1

HCID 586593281-(4-Ethyl-phenyl)-3-[4-(6-trifluoromethyl-pyrimidin-4-yloxy)-phenyl]-urea

Versuchsvorschrift

The title compound is prepared as described in Example 102 but using 4-(6-trifluoromethyl-pyrimidin-4-yloxy)-phenylamine (Example 114) and 4-ethyl-phenyl-isocyanate. The reaction mixture is stirred for 2.5 h. The title compound is obtained as a white solid: ES-MS: 403.0 [M+H]+; single peak at tR=9.72 min (System 2).

Aufarbeitung

  1. customThe title compound is prepared

Quellen und Nachweise

ORD-Eintrag
ord-eee240416961411d9ff20cdbf0dbebcf
Quelldatensatz
uspto-grants-2010_01
Patentnummer
US07652022B2

Notizen zur Reaktion

Wird geladen…