反应详情

温度

70 °C

A mixture of 4-(4-amino-phenoxy)-pyridine-2-carbonitrile (Example 102) (2.6 g, 12.3 mmol), sodium azide (6.6 g, 102 mmol, 8.3 equiv), and ammonium chloride in DMF abs. (180 mL) is heated to 70° C. for 7.5 h, under an argon atmosphere. The reaction mixture is allowed to cool to rt, filtered through a glass sintered funnel and concentrated in vacuo. The residue is purified by silica gel (390 g) column chromatography (CH2Cl2/MeOH, 80/20) to afford the title compound as a beige solid: ES-MS: 255.0 [M+H]+; single peak at tR=3.98 min (System 2); Rf=0.20 (CH2Cl2/MeOH, 75/25).

1. temperatureto cool to rt
2. filtrationfiltered through a glass sintered funnel
3. concentrationconcentrated in vacuo
4. customThe residue is purified by silica gel (390 g) column chromatography (CH2Cl2/MeOH, 80/20)