2-Methyl-1-(4-nitro-2-(trifluoromethyl)phenyl)-1H-imidazole → 4-(2-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)aniline

HRID 1993583Notes

Reaction equation

HRID 1993583 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][C:8]=2[C:16]([F:19])([F:18])[F:17])[CH:4]=[CH:5][N:6]=1>CO.[Ni]>[CH3:1][C:2]1[N:3]([C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][C:8]=2[C:16]([F:19])([F:17])[F:18])[CH:4]=[CH:5][N:6]=1

Participants

4

Reactant 1

HCID 598224512-Methyl-1-(4-nitro-2-(trifluoromethyl)phenyl)-1H-imidazole

Product 1

HCID 549354784-(2-Methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)aniline

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

The title compound is generated from 2-methyl-1-(4-nitro-2-trifluoromethyl-phenyl)-1H-imidazole (Stage 152.2) by hydrogenation in the presence of Raney-Ni in MeOH during 14 h at rt: Rf (MeOH/CH2Cl2=1:5): 0.42; M+H=242.0; m.p.=217-219° C.

Sources & evidence

ORD record
ord-400bb8289a6f4ba09530533c603effdb
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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