2-Methylimidazole → 2-Methyl-1-(4-nitro-2-(trifluoromethyl)phenyl)-1H-imidazole

HRID 1993584Notes

Reaction equation

HRID 1993584 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[CH3:15][C:16]1[NH:17][CH:18]=[CH:19][N:20]=1>CO.C(Cl)Cl>[CH3:15][C:16]1[N:17]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[C:11]([F:14])([F:13])[F:12])[CH:18]=[CH:19][N:20]=1

Participants

4

Reactant 2

HCID 127492-MethylimidazoleHCID 1361982-Bromo-5-nitrobenzotrifluoride

Product 1

HCID 598224512-Methyl-1-(4-nitro-2-(trifluoromethyl)phenyl)-1H-imidazole

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared by hearing 1-bromo-4-nitro-2-trifluoromethyl-benzene and 2-methyl-imidazole between 100-150° C. during 15 h: M+H=272.0; Rf (MeOH/CH2Cl2=1:5): 0.60.

Workup

  1. custombetween 100-150° C.
  2. customduring 15 h

Sources & evidence

ORD record
ord-4c402a8c4a9f4514871c7c8f08c57bb3
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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