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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1993587Generated: October 30, 2026

Methylamine → [3-Methyl-4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-carbamic acid benzyl ester

https://huagongshe.com/reaction/1993587

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethylamineHCID 6329—
ReactantPropan-2-one--dichloromethane (1/1)HCID 21584124—
Reactant[4-(6-Chloro-pyrimidin-4-yloxy)-3-methyl-phenyl]-carbamic acid benzyl esterHCID 86605454—
SolventEthanolHCID 702—
Product[3-Methyl-4-(6-methylamino-pyrimidin-4-yloxy)-phenyl]-carbamic acid benzyl esterHCID 68537615—

Reaction Steps

The title compound is prepared from [4-(6-chloro-pyrimidin-4-yloxy)-3-methyl-phenyl]-carbamic acid benzyl ester by aminomethylation (30% CH3NH2 in EtOH, 60 min, rt): M+H=363.9; Rf (acetone/CH2Cl2=3:7): 0.26.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07652022B2
Source datasetuspto-grants-2010_01
ORD IDord-02ccafbcfcc84fd5b34eef0840b0cb1d
Source noteuspto-grants-2010_01