HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl chloroformate → benzyl N-(4-hydroxy-3-methylphenyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 5-Amino-2-hydroxytoluene | HCID 76081 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | benzyl N-(4-hydroxy-3-methylphenyl)carbamate | HCID 68538458 | — |
Reaction Steps
4-Amino-2-methyl-phenol (717 mg, 5.8 mmol) and benzyloxycarbonyl chloride (1.09 g, 6.4 mmol) are stirred in a suspension of AcOEt/concentrated Na2CO3 solution (50 mL/50 mL) for 7 h. The organic phase is concentrated under reduced pressure and flash chromatographed (silica gel, 3.8×66 cm, AcOEt/hexane=1:3): M+H=257.9; HPLC (System 1): 5.43 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07652022B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-0fc3d4811abf4273b435294bb40ebae4 |
| Source note | uspto-grants-2010_01 |