反应详情

4-Amino-2-methyl-phenol (717 mg, 5.8 mmol) and benzyloxycarbonyl chloride (1.09 g, 6.4 mmol) are stirred in a suspension of AcOEt/concentrated Na2CO3 solution (50 mL/50 mL) for 7 h. The organic phase is concentrated under reduced pressure and flash chromatographed (silica gel, 3.8×66 cm, AcOEt/hexane=1:3): M+H=257.9; HPLC (System 1): 5.43 min.

1. concentrationThe organic phase is concentrated under reduced pressure and flash
2. customchromatographed (silica gel, 3.8×66 cm, AcOEt/hexane=1:3)
3. custom5.43 min.