4-Ethylphenyl isocyanate → HCID 58659424, compound

HRID 1993590Notes

Reaction equation

HRID 1993590 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][C:7]2[N:12]=[CH:11][N:10]=[C:9]([NH2:13])[CH:8]=2)=[CH:4][CH:3]=1.[CH2:16]([C:18]1[CH:23]=[CH:22][C:21]([N:24]=[C:25]=[O:26])=[CH:20][CH:19]=1)[CH3:17]>CN(C=O)C>[NH2:13][C:9]1[N:10]=[CH:11][N:12]=[C:7]([CH2:6][C:5]2[CH:14]=[CH:15][C:2]([NH:1][C:25]([NH:24][C:21]3[CH:22]=[CH:23][C:18]([CH2:16][CH3:17])=[CH:19][CH:20]=3)=[O:26])=[CH:3][CH:4]=2)[CH:8]=1

Participants

4

Reactant 2

HCID 900074-Ethylphenyl isocyanateHCID 586593986-(4-Aminobenzyl)pyrimidin-4-amine

Product 1

HCID 58659424HCID 58659424, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared as described in Example 102 but using 6-(4-aminobenzyl)-pyrimidin-4-ylamine, 4-ethyl-phenyl-isocyanate, and DMF as the solvent. The reaction mixture is stirred for 2 h. The title compound is obtained as a white solid: ES-MS: 348.0 [M+H]+; single peak at tR=6.94 min (System 2).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-807fe56ce63f4d75b7bce41fa9f6554f
Source dataset
uspto-grants-2010_01
Patent number
US07652022B2

Reaction notes

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